Non-A Hepatitis B Virus Genotypes in Antenatal Clinics, United Kingdom
نویسندگان
چکیده
In the United Kingdom, the National Screening Programme for identification of hepatitits B virus (HBV) infection in pregnant women uses HBV e antigen (HBeAg) and antibody to HBeAg (anti-HBe) as markers of infectivity to determine use of immunoglobulin for hepatitis B. Serum samples from 114 HBV-infected women were analyzed. Viral loads correlated with HBeAg/anti-HBe status and viral genotypes. Among 95 mothers whose serum contained anti-HBe, viral loads ranged between undetectable and 8.6 x 10(6) IU/mL (median 228 IU/mL). Ten (10.5%) of these mothers had plasma viral loads >10(4) IU/mL; 6 were infected with genotype E and one each with genotypes A, B, C, and D. All viruses had precore stop codon or basal core promoter mutations. Preponderance of genotypes other than A among antenatal mothers in the United Kingdom reflects increasing globalization and trends in immigration. HBeAg serostatus is no longer sufficiently accurate for inferring potential infectivity of pregnant HBV carriers.
منابع مشابه
Hepatitis B virus infection among Chinese residents in the United Kingdom.
OBJECTIVE To determine prevalence of hepatitis B virus (HBV) serological markers in Chinese residents in the United Kingdom. METHOD Retrospective case-controlled study between January 1997 and June 2000 in two genitourinary medicine (GUM) clinics. RESULTS 117 Chinese and 234 non-Chinese controls were studied. Baseline characteristics except marital status showed no difference. Overall preva...
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